Daim ntawv thov ntawm nab venom hemagglutinin txhaj
Snake venom class blood clotting enzyme muaj toxicity tsawg, ua haujlwm sai (5 ~ 30 feeb tom qab kev kho mob tuaj yeem tsim cov nyhuv hemostatic), kev ua tau zoo rau lub sijhawm ntev (tom qab ua haujlwm ntev 48 ~ 72 teev) thiab lwm yam, thiab siv dav hauv kev kho mob. los txo cov ntshav los yog los ntshav (xws li kev phais, tshuaj sab hauv, obstetrics thiab gynecology, ophthalmology, otolaryngology, qhov ncauj kab noj hniav thiab cov kab mob hemorrhagic), Nws kuj tseem siv tau los tiv thaiv los ntshav (piv txwv li, tshuaj ua ntej kev phais tuaj yeem zam lossis txo los ntshav. ntawm qhov chaw phais thiab tom qab phais).Raws li cov ntaub ntawv qhia, qhov ua tau zoo ntawm tus nab venom hemagglutinin hauv kev phais hemostasis thiab plab hnyuv los ntshav yog qhov zoo dua li ntawm phenolsulfonamides, sodium caroxesulfonate, vitamin K thiab lwm yam tshuaj hemostatic.
Snake venom hemagglutinin txhaj yav tas los muag hauv khw feem ntau suav nrog nab venom hemagglutinin txhaj (lub npe lag luam: Sulejuan), nab venom hemagglutinin txhaj (lub npe lag luam: Bangting), agkistrodon halys hemagglutinin txhaj (lub npe lag luam: Txawm li cas los xij, kev soj ntsuam xyuas pom tau tias tsis muaj. Qhov sib txawv tseem ceeb hauv hemostatic efficiency thiab qhov tshwm sim ntawm kev phiv tshwm sim ntawm peb tus nab.
Snake venom class blood clotting enzyme yog ib qho kev npaj lom neeg, los ntawm cov qauv tshuaj, belongs rau heterologous protein, thiab mast hlwb nyob rau hauv vivo los yog basophilic cell nto molecules, ib tug series ntawm cov tshuaj tiv thaiv nyob rau hauv lub cell, vascular active tshuaj, xws li histamine tso tawm, Cov tshuaj tiv thaiv qeeb, hom Ⅰ ua xua rau lub cev, kuj tuaj yeem cuam tshuam nrog cov enzyme muaj impurities.Nyob rau tib lub sijhawm, ob qho tib si kev phais mob thiab kev mob tom qab phais tuaj yeem ua rau mob hnyav (APR), xws li lub cev kub, nce ntshav qabzib, nce catabolism, tsis zoo nitrogen tshuav nyiaj li cas thiab nce ntshav plasma mob theem protein (APP) concentration.Nyob rau lub sijhawm no muab cov protein ntau allogenic, lub cev muaj kev ua xua, lossis txawm tias muaj kev tsis haum tshuaj loj.Zhao Shanshan et al.txheeb xyuas cov ntaub ntawv ntawm cov ntaub ntawv qhia txog qhov tsis zoo ntawm kev txhaj tshuaj nab venom hemagglutinase, thiab pom tias 57 ntawm 69 tus neeg mob tshwm sim tsis pub dhau 1 teev tom qab txhaj tshuaj, thiab 35 ntawm lawv tshwm sim hauv 1 ~ 5 feeb tom qab txhaj tshuaj.Cov tshuaj tiv thaiv kab mob sai sai, yog tias pom nyob rau lub sijhawm lossis kev tuav tsis raug, kev loj hlob sai ntawm tus kab mob thiab txaus ntshai, yuav ua rau muaj kev phom sij rau cov neeg mob.
Yog li ntawd, cov lus qhia yuav tsum tau tswj nruj me ntsis hauv kev siv tshuaj kho mob, thiab tus neeg mob keeb kwm kev kho mob, keeb kwm tshuaj, keeb kwm tsis haum thiab keeb kwm ntawm tsev neeg yuav tsum tau ua tib zoo nug ua ntej siv thawj zaug.Npaj cov tshuaj thiab cov khoom tsim nyog rau kev kho mob xwm txheej ceev ua ntej siv.Kev txhaj tshuaj ceev yuav tsum qeeb, thiab cov neeg mob cov cim tseem ceeb thiab lwm yam kev hloov pauv yuav tsum tau ua tib zoo saib thaum pib ntawm cov tshuaj.Tom qab ua tib zoo soj ntsuam rau ob peb feeb, cov neeg mob tuaj yeem tawm mus kom ntseeg tau tias tsis muaj qhov cuam tshuam tsis zoo.
