Daim ntawv thov ntawm Xya Antithrombotic Agents
Muaj ob hom proteins uas muaj cov nyhuv antithrombotic nyob rau hauv nab venom, ib tug muaj peev xwm Lub enzyme txuas nrog fibrinolytic enzyme hu ua fibrinolytic enzyme (plasmine, FLE). hydrolysis ntawm lwm yam coagulation yam thiab platelet membrane, nrog pom tseeb antithrombotic nyhuv.Lwm qhov yog los ntawm inhibiting Prothrombin npaj yog qhib kom ncua cov txheej txheem coagulation, thiab tsis muaj enzyme kev ua.
Cov enzyme no yog thawj zaug tsim los ntawm Atoda li al Thiab sib tham txog cov txheej txheem anticoagulation ntawm anticoagulant protein, Nws tau lees paub tias cov nyhuv ntawm coagulation factor IX los yog coagulation factor X ntawm calcium ion tsim 1: 1 complex kom ntev lub sij hawm coagulation;Tom qab ntawd, Lu et al.los ntawm Agkistrodon acutus nyob rau yav qab teb Anhui Ib qho tshuaj tiv thaiv coagulant ACFI raug cais tawm ntawm tus nab venom.Liu Qing Liang et al.pom tias ACFI muaj cov calcium ion, Nws kuj tau lees paub tias nws cov haujlwm anticoagulant thiab spatial qauv muaj feem xyuam rau calcium ions.Tom qab ntawd, Xu Xiaolong thiab lwm tus tau cais cov venom ntawm Agkistrodon acutus los ntawm Agkistrodon acutus los ntawm kev txhim kho kev sib cais Lwm yam anticoagulant yam ACFI Kuv. Txoj kev tshawb fawb txog kev siv tshuab pom tau tias nws zoo ib yam li AC FI thiab nyob rau hauv qeb thib ob.Zhai Ning et al.cais ib qho tshuaj tiv thaiv coagulant los ntawm cov venom ntawm Agkistrodon acutus, thiab Nws lub cev thiab tshuaj muaj zog tau kawm, thiab nws tau pom tias nws tsis muaj kev ua haujlwm fibrinolytic thiab tsis muaj phospholipase A 2 kev ua haujlwm thiab los ntshav.Qian Xiaojiang thiab lwm tus tau cais cov venom ntawm Agkistrodon acutus los ntawm Hunan Lub fibrinolytic active tivthaiv raug cais thiab paub tseeb los ntawm thrombolytic kuaj nyob rau hauv vitro Nws muaj pom tseeb thrombolytic nyhuv.Lei Danqing tau sib cais los ntawm peb txoj kev chromatography Thiab cov kev ua ntawm plasmin tau zoo heev.Vim hais tias cov plasmin tivthaiv muaj Cov los ntshav tivthaiv yog qhov nyuaj rau kev sib cais, thiab nws cov nqi kho mob tsis pom tseeb.Li Zhaoyan et al Los ntawm kev siv zog kom tau txais fibrinolytic enzyme yam tsis muaj los ntshav Cheebtsam Kev txhawb nqa yog muab los ntawm.Zhou Xianli [18] ua pov thawj los ntawm kev sim uas Thrombin zoo li enzyme thiab plasmin los ntawm Agkistrodon halys venom muaj cov nyhuv thrombolytic pom tseeb, tab sis Cov nyhuv ncaj qha ntawm plasmin muaj zog dua li ntawm thrombin zoo li enzyme, Yog li ntawd, thrombin zoo li enzyme yog tus neeg ua haujlwm qeeb thrombolytic, uas. ua kom cov hlab ntsha rov ua kom rov zoo li qub, Txhim kho qhov kev kam rau ntawm cov hlab ntsha hauv thaj tsam ischemic, thiab muaj sia nyob ntawm cov hlab ntsha tawg los ntawm cov ntshav perfusion Cleavage muaj txiaj ntsig zoo rau lub sijhawm ntxov ntawm thrombosis, thiab ob qho tib si siv ua ke, Nws tuaj yeem txo qis. Qhov ntau npaum li cas thiab ua tiav anticoagulant thiab thrombolytic teebmeem.Kev siv xya Antithrombotic Agents Muaj ob hom proteins uas muaj cov nyhuv antithrombotic nyob rau hauv nab venom, ib tug muaj peev xwm Lub enzyme txuas nrog fibrinolytic enzyme hu ua fibrinolytic enzyme (plasmine, FLE). degrading fibrin thiab fibrinogen, Tsis muaj kev ua kom plasminogen hauv tib neeg lub cev, tsis muaj hydrolysis ntawm lwm yam coagulation yam thiab platelet membrane, nrog pom tseeb antithrombotic nyhuv.Lwm qhov yog los ntawm inhibiting Prothrombin npaj yog qhib kom ncua cov txheej txheem coagulation, thiab tsis muaj enzyme kev ua.
Cov enzyme no yog thawj zaug tsim los ntawm Atoda li al Thiab sib tham txog cov txheej txheem anticoagulation ntawm anticoagulant protein, Nws tau lees paub tias cov nyhuv ntawm coagulation factor IX los yog coagulation factor X ntawm calcium ion tsim 1: 1 complex kom ntev lub sij hawm coagulation;Tom qab ntawd, Lu et al.los ntawm Agkistrodon acutus nyob rau yav qab teb Anhui Ib qho tshuaj tiv thaiv coagulant ACFI raug cais tawm ntawm tus nab venom.Liu Qing Liang et al.pom tias ACF muaj calcium ion Nws kuj tau lees paub tias nws cov haujlwm anticoagulant thiab spatial qauv cuam tshuam nrog calcium ions.Tom qab ntawd, Xu Xiaolong thiab lwm tus tau cais cov venom ntawm Agkistrodon acutus los ntawm Agkistrodon acutus los ntawm kev txhim kho kev sib cais Lwm yam anticoagulant ACFI I Cov txheej txheem kev siv txoj kev tshawb fawb pom tias nws zoo ib yam li AC FI thiab belongs rau qeb thib ob.Zhai Ning et al.cais cov tshuaj anticoagulant tshiab los ntawm cov venom ntawm Agkistrodon acutus, thiab nws lub cev thiab tshuaj muaj zog tau kawm, thiab nws tau pom tias nws tsis muaj kev ua haujlwm fibrinolytic thiab tsis muaj phospholipase A 2 kev ua haujlwm thiab los ntshav.Qian Xiaojiang thiab lwm tus tau cais cov venom ntawm Agkistrodon acutus los ntawm Hunan Lub fibrinolytic active tivthaiv raug cais thiab paub tseeb los ntawm thrombolytic kuaj nyob rau hauv vitro Nws muaj pom tseeb thrombolytic nyhuv.Lei Danqing tau sib cais los ntawm peb txoj kev chromatography Thiab cov kev ua ntawm plasmin tau zoo heev.Vim hais tias cov plasmin tivthaiv muaj Cov los ntshav tivthaiv yog qhov nyuaj rau kev sib cais, thiab nws cov nqi kho mob tsis pom tseeb.Li Zhaoyan et al Los ntawm kev siv zog kom tau txais fibrinolytic enzyme yam tsis muaj los ntshav Cheebtsam Kev txhawb nqa yog muab los ntawm.Zhou Xianli [18] ua pov thawj los ntawm kev sim uas Thrombin zoo li enzyme thiab plasmin los ntawm Agkistrodon halys venom muaj cov nyhuv thrombolytic pom tseeb, tab sis Cov nyhuv ncaj qha ntawm plasmin muaj zog dua li ntawm thrombin zoo li enzyme, Yog li ntawd, thrombin zoo li enzyme yog tus neeg ua haujlwm qeeb thrombolytic, uas. ua rau cov hlab ntsha recanalization maj mam, Txhim kho cov kev kam rau ntawm cov hlab ntsha nyob rau hauv lub ischemic cheeb tsam, thiab ciaj sia lub vascular rupture los ntawm cov ntshav perfusion Cleavage muaj ib tug zoo tshwm sim nyob rau hauv thaum ntxov theem ntawm thrombosis, thiab ob leeg siv ua ke.
Nws tuaj yeem txo qhov ntau npaum li cas thiab ua tiav cov teebmeem anticoagulant thiab thrombolytic.
Post lub sij hawm: Oct-19-2022