Vim tias cov tshuaj suav tshuaj suav hais tias nws yog nyob rau hauv qeb ntawm "cov khoom noj nqaij thiab cov ntshav", nws muaj nuj nqis heev.Cov tshuaj suav tshuaj rau cov tsiaj muaj tshuaj lom ua lub luag haujlwm tseem ceeb hauv kev tshawb fawb thiab kev siv tshuaj ib txwm siv.Txawm li cas los xij, tam sim no, tsis muaj kev tshawb fawb me me ntawm cov khoom siv tshwj xeeb thiab cov txheej txheem ntawm kev ua ntawm cov tshuaj lom tsiaj feem ntau tshuaj hauv Suav teb.Lub ntsiab bottleneck yog tias nws cov khoom yog complex, nyuaj rau cais thiab purify, thiab nyuaj rau txheeb xyuas nws cov qauv.Lai Ren, Xiong Yuliang, Zhang Yun, Xiao Changhua, Wang Wanyu thiab lwm tus tswv cuab ntawm pab pawg tshawb fawb ntawm Kunming Institute of Zoology, Suav Academy ntawm Kev Tshawb Fawb tau ntev kawm txog cov khoom siv hauv paus thiab cov txheej txheem ntawm kev ua tau zoo ntawm cov tshuaj suav tshuaj rau cov tsiaj txhu, tau tsim kom muaj ib lub tsev qiv ntawv muaj txiaj ntsig zoo molecular, tsim ntau yam tshuaj tshiab, thiab maj mam tsim "cov phiaj xwm thev naus laus zis thev naus laus zis ntawm kev ua haujlwm ntawm cov tshuaj suav tshuaj rau cov tsiaj muaj tshuaj lom raws li cov tswv yim ciaj sia taus".Cov yam ntxwv ntawm cov txheej txheem thev naus laus zis no yog: 1) theoretical innovation: noj cov tswv yim ciaj sia taus ntawm cov tsiaj muaj kuab lom raws li kev taw qhia theoretical los tshawb txog cov khoom ua haujlwm;2) Kev tsim kho tshiab: proteomics ua ke nrog kws tshuaj yog siv los taug qab kev sib cais thiab kev ua kom huv ntawm cov khoom siv ua haujlwm;3) Integrated innovation: tsim ib lub hom phiaj mining thev naus laus zis rau kev ua haujlwm ntawm cov tsiaj txhu thiab cov tshuaj suav tshuaj raws li cov tswv yim muaj sia nyob, txheeb xyuas cov khoom siv rau lawv cov tswv yim ciaj sia, thiab nthuav tawm cov khoom siv hauv paus thiab kev ua haujlwm ntawm cov tshuaj suav tshuaj.Los ntawm cov txheej txheem kev kawm no, lawv tau txheeb xyuas qhov mob nyem, hemostasis, antithrombotic, hypotensive, tiv thaiv qog noj ntshav, tiv thaiv kab mob, tiv thaiv oxidation, tiv thaiv rheumatic mob caj dab Immune regulation thiab lwm yam tseem ceeb active molecules qhia lub hauv paus rau cov khoom siv tshuaj no kom ua tau zoo. , thiab ncaj qha ua pov thawj qhov ua tau zoo ntawm hom tshuaj suav tshuaj no ntawm qib molecular;Nyob rau tib lub sijhawm, nws kuj tau txheeb xyuas qee yam tshuaj uas ua rau muaj kev tsis haum, los ntshav thiab lwm yam kev mob tshwm sim, muab kev taw qhia rau kev nyab xeeb ntawm cov khoom siv tshuaj no.Qhov kev ua haujlwm no tau tsim lub hauv paus ruaj khov rau kev kho tshiab ntawm cov tshuaj suav tshuaj niaj hnub thiab kev tshawb fawb thiab kev tsim cov tshuaj tshiab rau cov tshuaj no.Nws tau txais 30 invention patents thiab 1 utility model patent, uas tau ua zoo scientific, kev sib raug zoo thiab kev lag luam tus nqi, feem ntau yog reflected nyob rau hauv: 1) nthuav qhia cov khoom xyaw tshwj xeeb zoo ntawm cov tsoos suav tshuaj ntawm qib molecular.Lawv tau txheeb xyuas ntau dua 800 lub cev ua haujlwm los ntawm cov khoom siv tshuaj no (xws li tshuaj tua kab mob peptides, bradykinin, tachykinin, antithrombotic peptides, protease inhibitors, proteases, bombesin, antioxidant peptides, immunosuppressants, phospholipase, thiab lwm yam tshuaj lom ntawm daim tawv nqaij. thiab txheeb xyuas lawv cov qauv, cov hom phiaj ua thiab cov txheej txheem;2) Kev txheeb xyuas cov pab pawg molecular zoo muab lub hauv paus kev tshawb fawb rau kev tsim, ua thiab siv cov qauv no rau cov tshuaj suav tshuaj;3) Kev txheeb xyuas cov tshuaj uas muaj tshuaj lom neeg xws li kev ua xua hauv cov tshuaj suav tshuaj ntsuab no muab ib txoj hauv kev rau kev sib cais thiab tshem tawm cov tshuaj lom thiab cov kev mob tshwm sim hauv Suav tshuaj ntsuab no, thiab muab tswv yim rau kev kuaj mob thiab kev tiv thaiv ntawm xws li tshuaj ntsuab tshuaj lom Suav;4) Qee cov active molecules muab tau los ntawm cov tsiaj co toxins tau tsim los rau hauv cov tshuaj kho mob los yog tab tom txhim kho, xws li cobra polypeptide neurotoxin polypeptide, agkistrodon acutus venom thrombin, vespid polypeptide, gadfly anti laren, yug hauv 1972, kws tshawb fawb thiab kws kho mob lub koom haum ntawm K. Zoology, Suav Academy ntawm Sciences, tus yeej ntawm National Science Fund rau Distinguished Young Scholars, thiab qhia cov txuj ci nyob rau hauv "Hundred Talents Program" ntawm Suav Academy ntawm Sciences nyob rau hauv 2004. Raws li lub ib hlis ntuj 2014, 125 SCI cov ntaub ntawv tau luam tawm raws li thawj los yog tus sau sau, xws li Proc Natl Acad Sci, Mol Cell Proteomics, Ntshav siab, thiab lwm yam;Caw los ua tus thawj tswj hwm ntawm J Venom Res;Nws tau thov rau ntau tshaj 70 invention patents.Nws tau ua tiav cov haujlwm tseem ceeb ntawm National Natural Science Foundation ntawm Tuam Tshoj, National Science Fund rau Cov Tub Ntxhais Kawm Txuj Ci, 973 Txoj Haujlwm ntawm Ministry of Science thiab Technology, qhov kev tshawb fawb tseem ceeb tshiab tshuaj, thiab cov kev taw qhia ntawm Suav Academy. ntawm Sciences.Nws tau ua tiav yeej National Technological Invention Award (2013, qeb duas thawj), Tuam Tshoj Cov Hluas Science thiab Technology Award (2011), Tan Jiazhen Life Science Award (2010) thiab lwm yam kev qhuas.Thrombotic polypeptide, centipede polypeptide, thiab lwm yam;5) Peb tau tsim cov kev kho mob rau nab venom thiab muv venom lom, muab kev siv tau zoo rau kev kho cov neeg mob uas muaj nab venom thiab muv venom lom.Kunming Institute of Zoology, Suav Academy ntawm Kev Tshawb Fawb tau ua tiav cov txiaj ntsig kev tshawb fawb zoo tshaj plaws hauv cov haujlwm tseem ceeb: hauv xyoo tas los no, nws tau luam tawm ntau dua 200 SCI cov ntaub ntawv, thiab yeej 4 lub xeev thiab thawj qhov khoom plig thiab 6 thib ob khoom plig.Xyoo 2013, Kunming Institute of Zoology, Suav Academy ntawm Kev Tshawb Fawb tau yeej qhov khoom plig thib ob ntawm National Technological Invention Award rau qhov project "Directional Mining Technology System for Functional Components of Toxic Animal Traditional Chinese Medicine Based on Biological Survival Strategy".
Post lub sij hawm: Dec-09-2022