[Cov Lus Qhia] Lub Hom Phiaj Kom cais thiab ntxuav cov protein ntau los ntawm Agkistrodon acutus venom nyob rau yav qab teb Anhui thiab saib xyuas nws cov nyhuv inhibitory rau tib neeg vascular endothelial hlwb.Txoj kev Tib neeg vascular endothelial hlwb EC-304 tau coj mus kuaj hauv vitro.CCK-8 colorimetry tau siv los txiav txim cytotoxicity ntawm anticoagulant protein feem ntawm Agkistrodon halys venom ntawm EC-304 hlwb kab lis kev cai hauv vitro.Phase contrast microscopy tau siv los soj ntsuam cov kev hloov pauv hauv cell morphology thiab biochemistry ntawm EC-304 hlwb kho nrog cov tshuaj tiv thaiv kab mob protein feem ntawm Agkistrodon halys venom.Cov txiaj ntsig Anticoagulant protein feem ntawm Agkistrodon halys venom tau pom tseeb kev loj hlob inhibition ntawm EC-304 hlwb (P μ Lub anticoagulant protein feem ntawm Agkistrodon halys venom (g / mL) muaj zog inhibitory nyhuv ntawm EC-304 hlwb, thiab tus nqi inhibition nce. Nrog rau qhov nce ntawm koob tshuaj; Lub EC-304 hlwb kho nrog anticoagulant protein los ntawm Agkistrodon halys venom pom kev hloov morphological. Nyob rau hauv lub microscope, lub hlwb yog puag ncig, tus naj npawb ntawm tshem tawm cov cell nce, tus naj npawb ntawm cell faib theem txo, thiab cov Tus naj npawb ntawm cov kab mob ntawm tes hauv cov kab lis kev cai nruab nrab tau nce ntxiv. Cov lus xaus Cov tshuaj tiv thaiv kab mob ntawm cov kab mob ntawm Agkistrodon acutus venom los ntawm yav qab teb Anhui xeev muaj zog inhibitory nyhuv ntawm EC-304 hlwb, thiab inducing apoptosis ntawm EC-304 hlwb yuav yog ib qho ntawm nws cov txheej txheem.
Post lub sij hawm: Dec-29-2022