Lub koom haum ntawm Snake Venom thiab Snakebite, Southern Anhui Medical College
Lub koom haum tshawb fawb ntawm Wuhu City, Anhui xeev
Kev tshawb fawb txog nab venom thiab nab qhov txhab ntawm Southern Anhui Medical College pib nyob rau hauv nruab nrab-1970s, thiab yog ib tug tswv cuab ntawm Anhui Provincial Snake Wound Treatment Group thaum lub sij hawm ntawd.Nws yog ib lub tsev kawm ntawv ntxov tshaj plaws los ua cov kev tshawb fawb thiab kev tshawb fawb txog nab venom hauv Suav teb.
Suav npe
Lub koom haum ntawm Snake Venom thiab Snakebite, Southern Anhui Medical College
qhov chaw
Anhui xeev
hom
kawm tiav tsev kawm ntawv
khoom
Nab Poison thiab Nab Qhov txhab
Kev tshawb fawb ua tiav ntawm lub koom haum
Taw qhia rau lub koom haum
Kev tshawb fawb txog nab venom thiab nab qhov txhab ntawm Southern Anhui Medical College pib nyob rau hauv nruab nrab-1970s, thiab yog ib tug tswv cuab ntawm Anhui Provincial Snake Wound Treatment Group thaum lub sij hawm ntawd.Xyoo 1984, nyob rau hauv kev coj noj coj ua ntawm Xib Fwb Wen Shangwu, tus thawj coj ntawm lub tuam tsev qhia ntawv thiab tshawb fawb ntawm cov tub ntxhais kawm mob thawj zaug, Lub Chaw Haujlwm Tshawb Fawb Snake Poison thiab Snakebite tau tsim, uas yog ib lub tsev kawm ntxov tshaj plaws los ua cov kev tshawb fawb thiab kev tshawb fawb. ntawm nab venom nyob Suav teb.Xyoo 2007, Snake Poison thiab Snakebite Research Office tau hloov npe rau Snake Poison Research Institute ntawm Southern Anhui Medical College, thiab tus thawj coj tam sim no yog xibfwb Zhang Genbao.Nyob rau hauv 30 xyoo dhau los, qhov yooj yim thiab siv cov kev tshawb fawb tau ua tiav ntawm venomous nab co toxins nyob rau yav qab teb Anhui tau ua ib qho tseem ceeb pab rau kev tiv thaiv thiab tswj cov nab raug mob thiab kev siv cov nab venom peev nyob rau hauv Tuam Tshoj;Lub ntsiab venomous nab nyob rau yav qab teb Anhui yog Agkistrodon acutus (Agkistrodon acutus), Agkistrodon acutus, Cobra, Green Bamboo Leaf Snake, Chromium Iron Head thiab Bungarus multicinctus, tshwj xeeb tshaj yog Agkistrodon acutus, uas cuam tshuam rau kev noj qab haus huv thiab lub neej ntawm cov neeg roob.Cov kev tshawb fawb tau pom tias cov nab venomous no feem ntau ua rau cov ntshav ncig co toxins thiab neurotoxins, uas tuaj yeem ua rau cov neeg mob raug kev txom nyem los ntawm kev sib kis ntawm cov hlab ntsha hauv lub cev (DIC) thiab ntshav los ntshav, poob siab, ntau yam hauv nruab nrog cev thiab lwm yam teeb meem loj;Los ntawm txoj kev tshawb fawb txog cov ntshav toxicology ntawm cov venom ntawm Agkistrodon acutus (Agkistrodon acutus) nyob rau yav qab teb Anhui, nws tau pom tias DIC cuam tshuam nrog nabbite yog ib qho ntawm cov cim qhia txog kev lom thaum ntxov, thiab txawv ntawm DIC qhia hauv ib txwm muaj. saib.Yog li ntawd, lub tswv yim ntawm "DIC zoo li" syndrome nyob rau hauv cov neeg mob tom los ntawm Agkistrodon acutus yog thawj zaug hauv Suav teb (1988), Nws kuj tau lees paub tias thrombin zoo li enzyme (TLE) thiab fibrinolytic enzyme (FE) muaj nyob rau hauv venom ntawm Agkistrodon acutus yog. qhov laj thawj tseem ceeb ntawm qhov "DIC nyiam" (1992).Qhov no yog qhov tseem ceeb heev los qhia meej txog cov yam ntxwv ntawm kev hloov ntshav hauv cov neeg mob Agkistrodon acutus, thiab tseem muab lub hauv paus theoretical rau kev siv cov tshuaj tua kab mob tshwj xeeb los kho qhov teeb meem no.Nyob rau hauv txoj kev tshawb no ntawm cov txheej txheem ntawm los ntshav los ntawm Agkistrodon acutus venom, nws kuj tau pom tias tus nab venom no muaj kev cuam tshuam rau peb yam tseem ceeb ntawm cov hemostatic system (coagulation yam, platelets thiab cov hlab ntsha phab ntsa), uas cov haemotoxin ncaj qha. cuam tshuam permeability ntawm capillaries.Nyob rau tib lub sijhawm, nws tau kawm tias los ntshav loj tshwm sim los ntawm Agkistrodon acutus venom lom thiab qhov nyuaj ntawm o ntawm cov ceg tawv raug mob kom txo qis yog cuam tshuam nrog kev cuam tshuam ntawm lymphatic ntxiv ntawm coagulation yam hauv cov hlab ntsha thiab cov hlab ntsha tsis zoo.Cov kev tshawb fawb yooj yim thiab siv tau yooj yim no tau ua lub luag haujlwm tseem ceeb hauv kev koom tes mus ntev nrog Qimen Snakebite Research Institute hauv kev tsim cov phiaj xwm kho mob rau cov kab mob venomous thiab ua kom muaj kev nyab xeeb ntawm cov neeg mob snakebite, thiab tau ua tiav cov txiaj ntsig tseem ceeb hauv zej zog.Cov kev tshawb fawb tau ua tiav tau yeej qhov Science thiab Technology Achievement Award ntawm Anhui Xeev, Science thiab Technology Progress Award ntawm Anhui Province (1993), thiab (A) qib Science thiab Technology Achievement Collective Award ntawm Ministry of Health (1991);Xyoo 1989, nws tau koom tes nrog Wuhan Lub Tsev Haujlwm ntawm Cov Khoom Siv Tshuaj lom neeg los tsim cov tshuaj tiv thaiv kab mob monoclonal tiv thaiv thrombin zoo li enzyme ntawm Agkistrodon acutus venom, uas yog thawj qhov kev vam meej hauv Suav teb;Xyoo 1996, nws tau sib koom ua ke thiab tsim cov khoom siv thrombin (YWYZZ 1996 No. 118004, patent CN1141951A) nrog lub koom haum ntawm Cov Khoom Siv Tshuaj lom neeg thiab tshuaj ntawm Jinan Tub Rog Thaj Chaw.
tshawb nrhiav pom
Nyob rau hauv xyoo tas los no, lub chaw soj nstuam tau cais thiab ntxuav ntau yam bioactive tshuaj los ntawm crude venoms ntawm Agkistrodon acutus, Agkistrodon halys thiab Cobra nyob rau yav qab teb Anhui, xws li anti hypercoagulable xeev enzymes, protein C activators (PCA).Cov kev tshawb fawb soj ntsuam tau lees paub tias cov khoom xyaw nquag tuaj yeem cuam tshuam rau cov txheej txheem coagulation, cuam tshuam rau platelet adhesion, sib sau ua ke thiab tiv thaiv kev ua haujlwm ntawm vascular endothelial hlwb, thiab muaj kev ua haujlwm siab thiab tsis tshua muaj toxicity anticoagulation thiab thrombolytic teebmeem, Qhov no tseem ceeb heev rau kev tiv thaiv thiab kho. ntawm cov kab mob thrombotic thiab txhim kho cov ntshav hypercoagulability;Nyob rau tib lub sijhawm, nws kuj tau pom tias PCA los ntawm nab venom muaj qhov tshwj xeeb ntawm kev tua K562 leukemia hlwb thiab inhibiting metastasis ntawm cov qog nqaij hlav cancer.Nws daim ntawv thov kev kho mob yav tom ntej yog dav heev.Lub chaw tshawb fawb tau ua tiav thiab ua tiav ntau txoj haujlwm tshawb fawb, xws li "Mechanism of DIC tshwm sim los ntawm Agkistrodon acutus venom", "Kev tshawb fawb txog cov txheej txheem ntawm cov ntshav los ntawm Agkistrodon acutus venom hauv cov tsiaj", "Kev kuaj mob ntawm cov nab thiab kev kuaj mob sib txawv ntawm nws. nab tsev neeg los ntawm enzyme labeling method ", tau nyiaj los ntawm National Natural Science Foundation, Ministry of Health, Department of Health thiab Department of Education ntawm Anhui Province;Tam sim no, cov phiaj xwm nyob rau hauv kev txhim kho muaj xws li: "Kev tshawb fawb ntawm cov txiaj ntsig ntawm pallas PCA los ntawm Agkistrodon acutus Venom tiv thaiv qog hlwb ", thiab kev sib cais thiab kev huv ntawm cov hlab ntsha analgesic Cheebtsam los ntawm Cobra Venom.
Lub koom haum tshawb fawb nab venom ntawm South Anhui Medical College muaj cov xwm txheej zoo, ua tiav cov cuab yeej tshawb fawb, cov qauv kev tshawb fawb tsim nyog, thiab kev nce qib hauv kev tshawb fawb thiab kev siv tshuab.Nws yuav tsum ua kom tiav tshiab hauv kev tshawb fawb tshawb fawb, kev cob qhia cov neeg ua haujlwm, thiab lwm yam. Cov peev txheej nab venom nyob rau yav qab teb Anhui yog nplua nuj thiab muaj txiaj ntsig heev.Snake venom pharmacy yog ib qho tshuaj uas muaj cai muaj tswv yim nyob hauv Suav teb.Cov kev tshawb fawb tau los ntawm lub hauv paus thiab kev siv cov nab venom thiab nws cov khoom tseem ceeb heev rau txoj kev loj hlob ntawm cov nplua nuj nab venom peev txheej nyob rau yav qab teb Anhui thiab daim ntawv thov kev kho mob.
Post lub sij hawm: Nov-11-2022