Snake venom muaj ntau yam khoom siv bioactive, feem ntau suav nrog protease thiab polypeptide
Nws suav txog li 90% ~ 95% ntawm qhov hnyav qhuav ntawm nab venom [l
Nrog rau kev txhim kho txuas ntxiv ntawm thev naus laus zis, ntau cov khoom siv roj ntsha lom neeg muaj nyob hauv nab venom yog maj mam
Nws tau raug cais thiab ntxuav, thiab tib neeg muaj
Ua qhov kev tshawb fawb tob rau nws nrog kev pom los siv cov khoom xyaw tshuaj zoo hauv nab venom rau tib neeg
Hauv kev kho mob zoo sib xws.Tam sim no, cov khoom xyaw nquag ntawm cov tshuaj muaj txiaj ntsig muaj nyob hauv nab venom
Kev tshawb fawb tshuaj thiab kev kho mob daim ntawv thov ua tiav yog tsom rau cov tshuaj tiv thaiv kab mob, hemostatic thiab hypoglycemic.
Siab, tshuaj tiv thaiv kab mob thiab tshuaj kho mob.
L Antithrombotic tshuaj
Tus nab venom protease nrog anti-thrombotic thiab thrombolytic teebmeem feem ntau suav nrog Ancelor.
Enzyme (hoe crod), batmxobin, defibrase (de coerase) thiab Agkistrodon acutus
Enzyme (acutobin).Thawj peb yog snaI [e venom
Thmmbin zoo li enzymes, s Ⅷ.E), sVTLE yog serine protease, tib yam li
Nws muaj arginine esterase thiab amidase kev ua haujlwm - 1. Snake venom thrombin-zoo li enzyme
Nws ua rau fibrinogen tso tawm fibrinogen A lossis B, yog li
Nws tuaj yeem coagulate lub polymerization ntawm fibrin monomer lub taub hau thiab tus Tsov tus tw, vim nws qhia thrombin
Muaj nuj nqi thiab hu ua thrombin-zoo li.Nyob rau tib lub sijhawm, nab venom thrombin-zoo li enzyme tsis tuaj yeem pom hauv tib neeg
Activates coagulation factor x Ⅲ hauv vivo, thiab fibrin monomer tsim los ntawm nws cov hydrolysis tuaj yeem
Lub taub hau thiab tus Tsov tus tw polymerization, tab sis tsis tuaj yeem tsim cov saw hlau sib txuas, uas yooj yim rau kev puas tsuaj los ntawm ntuj reticuloendothelial system.
Lub plasma fibrinogen theem yog txo vim phagocytosis los yog degradation los ntawm fibrinolytic system.
Nws yog nyob rau hauv ib tug benign fibrinolytic xeev, yog li nws qhia anticoagulation thiab kev nyuaj siab nyob rau hauv lub cev
Fibrillation H1.Agkistrodon acutus enzyme belongs rau fibrinolytic enzyme, uas yog fibrinolytic
Cov ntawv luv ntawm cov enzyme [Erin (ogen) ol "icenzyme, FLE] tuaj yeem muab faib ua ib txoj saw
Zinc metalloproteinase thiab ib leeg-chain lossis ob-chain serine protease, feem ntau zinc hlau qe
Dawb enzyme.Snake venom fibrinolytic enzyme tsis xav tau kev ua kom cov activator, thiab tuaj yeem txiav cov fibers ncaj qha.
Cov protein (protogen) tsim hemofibrin, yog li nws yuav tsis ua kom sib sau "J.
Los ntawm cov venom ntawm Agkistrodon halys (xws li sek, № r [md ∞ mus, nkoj) hauv Malaysia
Cov ankylose cais tawm yog thawj zaug siv rau hauv kev kho mob ntawm cov kab mob thrombotic
SVTLE tshuaj.6 J. Tom qab kev txhim kho ntawm Ancelos, ib zaug nws tau kawm los ntawm ntau lub tebchaws
Cov kws tshawb fawb ntseeg tias sV'11E yog cov tshuaj cog lus tshaj plaws rau kev kho mob thrombotic,
Ntxiv nrog rau kev siv rau kev kho mob ntawm peripheral thrombosis, nws kuj tseem siv tau rau kev kho mob ntawm cov hlab ntsha sib sib zog nqus venous thrombosis thiab central venous thrombosis.
Pulse thrombosis kuj muaj cov nyhuv curative "J.Los ntawm xyoo 1990, ntau lub tebchaws thiab cheeb tsam
Qu Du txaus siab heev rau kev kho mob cerebral ischemia thiab mob stroke nrog aclase, thiab
Cov phiaj xwm nyiaj txiag: Tub Rog Kev Tshawb Fawb Txog Kev Tshawb Fawb thiab Kev Tshawb Fawb Txog Kev Tshawb Fawb Cov Hluas (13QNP068);Tag nrho cov tub rog "12
5 “kev tshawb fawb txog kev kho mob dav dav (cwslJ280);Chengdu Tub Rog Cheeb Tsam "12th Tsib Xyoo Npaj" Kev Tshawb Fawb Kev Kho Mob
Tej yaam num tseem ceeb (B12026);Kev tshawb fawb txog kev kho mob dav dav ntawm Chengdu Tub Rog Cheeb Tsam thaum lub sijhawm 12th Tsib Xyoo Npaj
(C12062)
Tus sau chav tsev: 650032 Kunming, Chengdu Tub Rog Cheeb Tsam Chaw Tiv Thaiv thiab Tiv Thaiv Kab Mob (Zhang Zhixiao,
Hu Tingsong, Cui Qinghua, Zheng Ying, Fan Quanshui);Pathogens, Tsev Kawm Ntawv ntawm Cov Tshuaj Kho Mob, Youjiang Medical College rau Haiv Neeg
Biology thiab Immunology Qhia thiab Tshawb Fawb Chaw Haujlwm (Xie Zhenfeng)
Tus sau: Fan Quanshui, E-mail: fqsl68@126 .com
Ntau qhov kev tshawb fawb me me tau ua tiav.Initial drug use index
Tsis tas li ntawd, Ancelos tuaj yeem siv rau hauv kev kho mob ntawm cov neeg mob uas mob stroke ischemic nyob rau theem pib.
Nws qhia tau hais tias zoo curative nyhuv.Tom qab ntawd, nrog loj-scale randomized ob-dig muag, placebo khub
Raws li kev sim tshuaj, nws, thiab lwm yam. Rau 2613 tus neeg mob
Cov tshuaj kho tau ntawm cov neeg mob uas muaj kev sib deev ischemic stroke tau lees paub tias cov neeg mob hauv pawg cloroxobin
Cov ciaj sia taus tau nce ntxiv, tab sis qhov kev pheej hmoo ntawm intracranial hemorrhage kuj tau nce ntxiv.Tom qab ntawd
Qhov kev sim tshuaj ntsuam xyuas ntawm 1222 cov neeg mob uas mob stroke ischemic tau lees paub tias tom qab 3 teev
Ancelose tsis pom zoo rau kev kho mob.1…. Teb Chaws Asmeskas thiab Canada luam tawm xyoo 2009
500 strokes koom nrog 12 lub teb chaws thiab cheeb tsam suav nrog Canada thiab Australia
raug kev txom nyem los ntawm
Post lub sij hawm: Feb-26-2023