nab venom

Snake venom yog ib tug kua uas secreted los ntawm venomous nab los ntawm lawv venomous qog.Nws lub ntsiab tivthaiv yog cov tshuaj lom protein, suav txog 90% mus rau 95% ntawm qhov hnyav qhuav.Muaj txog 20 hom enzymes thiab co toxins.Tsis tas li ntawd, nws kuj muaj qee qhov me me molecular peptides, amino acids, carbohydrates, lipids, nucleosides, lom amines thiab hlau ions.Cov muaj pes tsawg leeg ntawm nab venom yog complex, thiab toxicity, pharmacology thiab toxicological teebmeem ntawm txawv nab venoms muaj lawv tus yam ntxwv.Ntawm lawv, cov co toxins tau qhia raws li hauv qab no: 1. Cov ntshav ncig co toxins: (xws li viper venom, agkistrodon acutus venom, caltrodon venom, ntsuab nab venom) 2. Neurotoxins: (qhov muag nab venom, kub nplhaib nab venom, silver nplhaib nab venom. , huab tais nab venom, rattlesnake venom) 3 Mixed toxins: (Agkistrodon halys venom, Ophiodon halys venom) ① Anti-cancer effect of nab venom: cancer yog ib qho ntawm peb kab mob loj uas ua rau tib neeg noj qab haus huv, thiab tsis muaj kev kho mob zoo ntawm tam sim no.Cov kws tshawb fawb los ntawm txhua lub teb chaws tab tom ua txoj kev tshawb fawb ntawm nab venom ua ib thaj chaw tshiab los daws qhov teeb meem no.Snake Venom Research Office ntawm Tuam Tshoj Medical University tab tom sim nrhiav cov khoom xyaw zoo uas tuaj yeem cuam tshuam cov qog loj hlob los ntawm Agkistrodon halys venom tsim nyob rau hauv Dalian, Liaoning, Ib qho kev sib piv qog inhibition kuaj tau nqa tawm ntawm thawj venom thiab cais venom ntawm Agkistrodon halys Pallas. .Cuaj qhov sib txawv ntawm tus nab venom muaj ntau qib ntawm inhibition ntawm nas sarcomas, thiab cov qog inhibition yog siab li 87.1%.② Anticoagulant nyhuv ntawm nab venom: lub "defibrase" muab rho tawm los ntawm cov venom ntawm Agkistrodon halys acutus nyob rau hauv Yunnan, Tuam Tshoj, dhau qhov kev txheeb xyuas hauv xyoo 1981, thiab tau siv los kho 333 tus neeg mob vascular thrombosis, suav nrog 242 tus neeg mob cerebral thrombosis, kev ua tau zoo yog 86.4%.Agkistrodon halys antacid tsim los ntawm Tuam Tshoj Medical University thiab Shenyang Pharmaceutical College hauv kev koom tes tau ua tiav cov txiaj ntsig zoo hauv kev kho mob vascular occlusive kab mob.Tus nab venom antacid tsim los ntawm Snake Venom Research Office ntawm Tuam Tshoj Medical University tuaj yeem txo cov ntshav lipids, nthuav cov hlab ntsha, txo cov ntsiab lus ntawm thromboxane hauv cov ntshav, nce prostacyclin, thiab so vascular du nqaij.Nws yog ib qho zoo tshaj plaws los tiv thaiv-.③ Raws li rau cov nyhuv hemostatic ntawm nab venom, Nyiv siv cov coagulant txhawb cov khoom xyaw uas tau hais hauv vipers siv rau kev phais, tshuaj sab hauv, lub ntsej muag, gynecology thiab obstetrics thiab lwm yam kab mob hemorrhagic.Cov tshuaj hu ua "reptilin txhaj".④ Kev npaj cov tshuaj tua kab mob: Kev txhim kho ntawm cov tshuaj tua kab mob hauv Suav teb tau pib hauv xyoo 1930.Tom qab kev ywj pheej, Shanghai Lub Tsev Kawm Ntawv ntawm Cov Khoom Siv Hluav Taws Xob, hauv kev koom tes nrog Snake Research Group ntawm Zhejiang Medical University, Zhejiang Institute of Traditional Chinese Medicine, thiab Guangzhou Medical College, tau ua tiav cov tshuaj tua kab mob zoo rau Agkistrodon halys, Agkistrodon acutus, Bungarus multicinctus, thiab Ophthalmus.⑤ Cov nyhuv analgesic ntawm nab venom: Xyoo 1976, Yunnan Kunming Tsiaj Tshawb Fawb Lub Tsev Kawm Ntawv tau ua tiav "Ketongling" los ntawm cov venom ntawm nab venom, uas yog siv los kho ntau yam mob thiab tau ua tiav cov nyhuv analgesic tshwj xeeb.Cov "compound Ketongning" tsim los ntawm Cao Yisheng tau pom tias muaj txiaj ntsig zoo hauv kev kho mob paj hlwb, mob qog noj ntshav thiab detoxification.Vim hais tias tus nab venom analgesic muaj ntau dua kev ua ub ua no thiab tsis muaj yees, nws tau siv tshuaj kho mob los hloov morphine hauv kev kho mob cancer lig.Cov venom ntawm venom tuaj yeem siv los npaj tshwj xeeb cov tshuaj tiv thaiv kab mob, tshuaj tua kab mob thiab cov tshuaj hemostatic.Nws cov nyhuv yog zoo dua li morphine thiab dolantin, thiab nws tsis yog tshuaj.Snake venom tseem tuaj yeem kho tus tuag tes tuag taw thiab polio.Nyob rau hauv xyoo tas los no, nab venom tau siv los kho mob qog noj ntshav.Vim hais tias nab venom yog ib tug compound uas muaj li ntawm 34 proteins, ib qho tseem ceeb heev thiab ib tug loj tus naj npawb ntawm co toxins hu ua cytolysin.Nws yog ib qho tshuaj lom uas tshwj xeeb rhuav tshem cov cell thiab cell membranes.Qhov no yuav tsim malignant qog.Yog hais tias cytolysin los ntawm nab venom raug cais thiab txhaj rau hauv tib neeg lub cev kom kis tau thoob plaws lub cev nrog cov ntshav ncig kom tua cov qog nqaij hlav cancer, muaj kev cia siab zoo los kov yeej qhov nyuaj ntawm kev kho mob qog noj ntshav.Lub defibrase rau kev txhaj tshuaj yog muab rho tawm los ntawm cov venom ntawm Agkistrodon acutus hauv Suav teb.Nws muaj cov haujlwm ntawm kev txo cov fibrinogen thiab thrombolysis, thiab yog ib qho tshuaj tshwj xeeb rau kev kho cov kab mob plawv.Yim qhov tseem ceeb ntawm kev siv nab venom yog: 1. kev kho mob qog noj ntshav thiab tiv thaiv qog noj ntshav, tiv thaiv qog;2. Hemostasis thiab