Snake Venom Los ntawm Agkistrodon (tsib-kauj ruam Snake) Yuav tsum tau kho nrog Antihematic Serum

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Ob qhov kev sim tshuaj tau ua, kev sim tshuaj placebo-tswj randomized thiab tswj tau qhov zoo-tswj randomized sim.Tag nrho cov qhov txhab tau los ntshav los ntawm incision ntawm lub plab phab ntsa hauv plab phais.Lub ntsiab kev kho mob indexes yog ntshav poob, lub sij hawm hemostasis thiab ntshav poob ib chav tsev.Randomized placebo hauv kev sim tshuaj hauv 180 tus neeg ntawm tib neeg: kev faib ua feem ntawm cov ntsiab lus sib npaug rau cov placebo, 2 u thiab 3 u peb pawg, preoperative 15-20 feeb ib zaug txhaj tshuaj, cov txiaj ntsig tau qhia ob koob tshuaj no hauv cov ntshav, lub sijhawm los ntshav thiab ntshav poob rau ib chav tsev qhov ntsuas tau zoo dua rau cov placebo, tab sis tsis muaj kev sib txuas lus teb ntawm ob pawg.Hauv kev sim tswj qhov zoo, muaj 324 tus neeg mob hauv pawg sim thiab 108 tus neeg mob hauv pawg tswj hwm, thiab ib koob tshuaj 2U tau muab rau hauv pawg sim 15-20 feeb ua ntej kev phais los ntawm kev txhaj tshuaj ib zaug.Tsis muaj kev phiv tshwm sim hauv cov kev sim saum toj no.

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Cov kev tshawb fawb tau pom tias cov nab venomous no feem ntau tsim cov ntshav ncig cov co toxins thiab neurotoxins, uas tuaj yeem ua rau muaj kev cuam tshuam ntawm intravascular coagulation (DIC) thiab tom qab los ntshav, poob siab thiab ntau lub cev tsis ua haujlwm.Raws li kev tshawb fawb ntawm cov ntshav toxicology ntawm nab venom nyob rau yav qab teb Anhui, DIC tau pom tias yog ib qho ntawm cov yam ntxwv ntawm tus nab raug mob cov neeg mob uas muaj tshuaj lom thaum ntxov, uas txawv ntawm cov lus qhia ntawm DIC.Yog li ntawd, lub tswv yim ntawm "DIC zoo li" syndrome nyob rau hauv cov neeg mob nab tom tau thov thawj zaug hauv Suav teb (1988).Nws tau pom tias TLE thiab FE yog qhov laj thawj tseem ceeb ntawm qhov "DIC nyiam" (1992).Qhov no yog qhov tseem ceeb heev los qhia txog cov yam ntxwv ntawm cov ntshav hloov hauv cov neeg mob uas muaj tsib-kauj ruam nab venom, thiab tseem muab lub hauv paus theoretical rau kev siv cov tshuaj tua kab mob tshwj xeeb los kho qhov teeb meem no.

Hauv kev tshawb fawb txog cov txheej txheem los ntshav tshwm sim los ntawm tsib-kauj ruam nab venom, nws tseem pom tau tias tus nab venom no muaj kev cuam tshuam rau peb yam ntawm lub cev hemostatic system (coagulation yam, platelets thiab cov hlab ntsha phab ntsa), uas los ntshav. Toxin ncaj qha cuam tshuam rau permeability ntawm capillaries.Nyob rau tib lub sijhawm, nws tau pom tias los ntshav hnyav thiab qhov o ntawm cov ceg tawv nqaij raug mob tsis yooj yim los daws, uas cuam tshuam rau kev cuam tshuam ntawm cov ntshav ntawm cov hlab ntsha hauv cov hlab ntsha lymphatic coagulation thiab qhov tsis zoo tshaj tawm ntawm lymphatic flow.Hauv kev koom tes ntev nrog lub koom haum qimen Snakebite, cov kev tshawb fawb thiab kev siv cov kev tshawb fawb hauv paus tau ua lub luag haujlwm tseem ceeb hauv kev tsim cov phiaj xwm kho mob zoo rau cov neeg mob snakebite, thiab tau ua tiav cov txiaj ntsig tseem ceeb hauv zej zog.Cov kev tshawb fawb tau ua tiav tau yeej qhov Science thiab Technology Achievement Award ntawm Anhui Province, Science thiab Technology Progress Award ntawm Anhui Province (1993), Ministry of Health (A) Qib Science thiab technology Achievement Group Award (1991);Xyoo 1989, lub tuam txhab tau koom tes nrog Wuhan Lub Tsev Haujlwm ntawm Cov Khoom Siv Tshuaj lom neeg los tsim cov tshuaj tiv thaiv monoclonal tiv thaiv penta nab venom thrombin, uas yog thawj qhov kev vam meej hauv Suav teb.Nyob rau hauv 1996, lub tuam txhab koom ua ke tsim thiab tsim thrombin cov khoom nrog lub koom haum ntawm cov khoom lom thiab tshuaj ntawm Jinan tub rog Command (Yuwei Tshuaj Pom Zoo No. 118004, Patent CN1141951A).